解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Antiretroviral (ARV) prophylaxis for prevention of mother to child transmission (MTCT) of HIV could affect hemoglobin (Hb) development of infants. A cross-sectional descriptive study was conducted in 24 HIV-infected and 21 HIV-uninfected pregnancies. ARV drugs were administered to HIV-infected pregnancies at 21 weeks ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x12666140713170800
更新日期:2014-01-01 00:00:00
abstract::Psychiatric illness is common in HIV-infected patients and underlines the importance for screening not only for cognitive impairment but also for co-morbid mental disease. The rationale for combining immunomodulatory neurokinin- 1 receptor (NK1-R) antagonists with combined antiretroviral therapy (cART) is based on mul...
journal_title:Current HIV research
pub_type: 杂志文章,随机对照试验
doi:10.2174/1570162x12666140526120831
更新日期:2014-01-01 00:00:00
abstract::The aim of the study was to report the epidemiological profile of HIV-1 positive patients from, Istanbul, Turkey, which has one of the lowest HIV-1/AIDS prevalences in Europe. The patients were followed by ACTHIV-IST group which was established by the Infectious Diseases Departments of five teaching hospitals (three u...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x12666140411111803
更新日期:2014-01-01 00:00:00
abstract::Enteroaggregative Escherichia coli (EAEC) have been isolated from both HIV-positive and non-HIV diarrheal samples. In this study a collection of 18 isolates from these two groups were compared for biofilm formation and antibiotic resistance and for the presence of 14 virulence-related genes. All the HIV-positive and o...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x12666140207161000
更新日期:2013-12-01 00:00:00
abstract:UNLABELLED:Adolescent girls throughout the globe are particularly vulnerable to HIV infection. In the U.S., sexually-active, adolescent girls in urban settings are at elevated risk for HIV. The purpose of this study was to describe a theoreticallydriven, HIV prevention intervention tailored for adolescent girls and eva...
journal_title:Current HIV research
pub_type: 杂志文章,随机对照试验
doi:10.2174/1570162x12666140129110129
更新日期:2013-10-01 00:00:00
abstract::Passive immunization studies in non-human primates have established unequivocally that virus neutralization can prevent infection, providing the impetus for current intense efforts to identify immunogens that elicit broadly neutralizing antibodies in humans. Although Fc-mediated effector function may also contribute t...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162x113116660060
更新日期:2013-07-01 00:00:00
abstract::HIV-associated neurocognitive disorders (HAND) remain prevalent despite effective combined anti-retroviral therapy (cART). Cognitive function has been shown to inversely correlate with decreased synaptic and dendritic density. In this study, macaques inoculated with SIV were examined over a 3-month course of infection...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x1131100049
更新日期:2013-06-01 00:00:00
abstract::Two HIV-1 non B isolates, 98US_MSC5007 and 98US_MSC5016, which have been identified amongst the US Army personnel serving abroad, are known to have originated from other nations. Notwithstanding, they are categorized as American strains. This is because their countries of origin are unknown. American isolates are basi...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x113119990046
更新日期:2013-06-01 00:00:00
abstract::The present study assessed the phenotypic aspects of oral-cavity Candida albicans isolates from 300 HIV-1- positive patients, relating the most commonly investigated virulence factors (enzyme typing and germ-tube formation) to the most common morphotypes. The samples were seeded into specific media for isolation and s...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x113119990042
更新日期:2013-06-01 00:00:00
abstract::Over the past 10 years substantial progress has been made in the implementation of prevention of mother-to-child transmission of HIV (PMTCT) interventions in Sub-Saharan Africa (SSA). In spite of this, new pediatric infections remain unacceptably high, contributing the majority (>90%) of the estimated 390,000 infectio...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162x11311020007
更新日期:2013-03-01 00:00:00
abstract::Beta defensins are antimicrobial peptides that serve to protect the host from microbial invasion at skin and mucosal surfaces. Here we explore the relationships among beta defensin levels, total bacterial colonization, and colonization by bacterial vaginosis (BV)-related bacteria and lactobacilli in the female genital...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016212802429848
更新日期:2012-09-01 00:00:00
abstract::Several studies have suggested that aerobic physical activity is safe and beneficial for HIV-infected adults. However, there is information lacking regarding whether HIV-infected patients practice physical activity and to what extent. Therefore, the aim of this systematic review was to determine the prevalence of phys...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212802429794
更新日期:2012-09-01 00:00:00
abstract::Opioid use in HIV infection has been associated with an increased frequency of neurological disease and cognitive impairment and vitamin A deficiency has been linked to progressive HIV disease in drug users. In this report the potential effects of these factors, alone and in combination, on gamma amino butyric acid (G...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016212802138715
更新日期:2012-07-01 00:00:00
abstract::The cellular protein "Bone marrow stromal antigen 2" (BST2 also called Tetherin, CD317, HM1.24) was identified as a major mediator of the innate immune defense against the dissemination of enveloped viruses. BST2 was shown to physically trap the de novo formed viral particles at the surface of infected cells, thereby ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212800792414
更新日期:2012-06-01 00:00:00
abstract::Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in mo...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212800618138
更新日期:2012-04-01 00:00:00
abstract::Interleukin 7 (IL7) is a critical factor for lymphocyte homeostasis. A dysfunction of the IL7/IL7R pathway has previously been described in HIV-1 infection, and promising results were observed in recent analyses of IL7 for therapeutic use in HIV infected individuals. However, further investigations are still warranted...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016212799937209
更新日期:2012-03-01 00:00:00
abstract::Since the beginning of the AIDS pandemic, and following the discovery of the human immunodeficiency virus (HIV) as the etiological agent of the disease, it was clear that the virus gains access to the human host predominantly through the mucosal tissue after sexual exposure. As a consequence, the female genital tract ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212799304689
更新日期:2012-01-01 00:00:00
abstract::The development of pre-exposure prophylactics or microbicide products for the reduction or elimination of the sexual transmission of HIV has numerous challenges or barriers to success. Historically traditional dosage forms such as gels have been developed in the field but more recently controlled release dosage forms ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212799304599
更新日期:2012-01-01 00:00:00
abstract::Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016211798998736
更新日期:2011-12-01 00:00:00
abstract::Antiretroviral therapy (ART), for those who have access, has revolutionised the morbidity and mortality consequences of HIV infection. By the end of 2010, 6.6 million people living with HIV in low- and middle-income countries were receiving ART, a dramatic 20-fold increase since 2001, saving millions of lives. In addi...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016211798038579
更新日期:2011-09-01 00:00:00
abstract::Premature immunosenescence has been reported in different HIV scenarios. However, how premature is the HIV-related immunosenescent phenotype is still unknown. Thus, the aim of this study was to analyze the immunosenescent status of young viraemic naive HIV-infected individuals, with less than four years from infection...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016211797636008
更新日期:2011-07-01 00:00:00
abstract::Although hepatitis B serology screening has been recommended for HIV care, it has not been routinely performed. We aimed to assess compliance and timing of hepatitis B serology screening among HIV-infected patients in a resource-limited setting. A cross-sectional study was conducted in Thailand. Compliance, timing of ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016211794582669
更新日期:2011-01-01 00:00:00
abstract::A major hurdle in the development of a global HIV-1 vaccine is viral diversity. For close to three decades, HIV vaccine development has focused on either the induction of T cell immune responses or antibody responses, and only rarely on both components. After the failure of the STEP trial, the scientific community con...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210794088290
更新日期:2010-12-01 00:00:00
abstract::While significant progress has been made since 2003 when a comprehensive treatment, prevention and control program was implemented to combat the HIV/AIDS epidemic in China, new challenges are emerging. There have been limited direct case reports on profiles of HIV/AIDS patients under care at unique clinical settings i...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016210793499169
更新日期:2010-10-01 00:00:00
abstract::Most new HIV infections in sub-Saharan Africa now occur in married and cohabiting couples, many of whom do not realize that only one of them may be infected with HIV. HIV-negative individuals living in stable HIV-discordant partnerships (in which one partner is HIV-infected while the other one is not) are twice as lik...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210793499303
更新日期:2010-09-01 00:00:00
abstract::Recently, a mechanism of negative regulation of immune responses by a specialized population of so-called regulatory T cells (Tregs) has become a focus of intense investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of Tregs differentiation and function, the complex bio...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210791208613
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:The primary objective of this study was to estimate etravirine activity in a cohort of patients infected with non-B subtype HIV-1 and failing nevirapine-based therapy. MATERIALS AND METHODS:Genotypic resistance testing was performed if viral load was >OR= 1,000 copies/ml after receiving at least six months o...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016210791111098
更新日期:2010-04-01 00:00:00
abstract:INTRODUCTION:Tuberculosis (TB) is a pandemic infectious disease especially frequent in HIV-infected patients. Toll-like receptor (TLR) 4 has been described to play a main role in the innate immunity against TB. In fact, single nucleotide polymorphisms (SNPs) in TLRs may influence AIDS disease progression. The associati...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016210791111052
更新日期:2010-04-01 00:00:00
abstract::Hodgkin lymphoma (HL) represents one of the most common types of a non-AIDS-defining tumour that occurs in the HIV population, and its incidence is increasing in the post Highly Active Anti-retroviral Therapy (HAART) era. Despite the aggressiveness of that disease, the outcome of patients with HIV-HL has improved with...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210790442704
更新日期:2010-03-01 00:00:00
abstract::Jembrana disease virus (JDV) is the most recently discovered member of the lentivirus family and causes an acute clinical disease in Bali cattle with a fatality rate of approximately 15%. It is genetically related to bovine immunodeficiency virus (BIV) to the extent that infections cannot yet be differentially diagnos...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210790416370
更新日期:2010-01-01 00:00:00
abstract::In the HAART era Kaposi's sarcoma (KS) remains the second most frequent tumor in HIV-infected patients worldwide, and it has become the most common cancer in Sub-Saharan Africa. In western countries the risk for KS in men having sex with men (MSM) is 5 to 10 times higher compared to other groups of individuals practic...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209789973619
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the potential impact of the current global economic crisis (GEC) on the spread of HIV. DESIGN:To evaluate the impact of the economic downturn we studied two distinct HIV epidemics in Southeast Asia: the generalized epidemic in Cambodia where incidence is declining and the epidemic in Papua New Gu...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209789973637
更新日期:2009-11-01 00:00:00
abstract::A current debate in the HIV-1 vaccine field concerns the ability of an immunodeficiency virus to elicit a protective response. One argument is that HIV-1 superinfections are frequent in healthy individuals, because virus evades conventional immune surveillance, a serious obstacle to vaccine design. The opposing argume...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209789346255
更新日期:2009-09-01 00:00:00
abstract::Drug use and HIV/AIDS are global public health issues. The World Health Organization (WHO) estimates that up to 30% of HIV infections are related to drug use and associated behaviors. The intersection, of the twin epidemics of HIV and drug/alcohol use, results in difficult medical management issues for the health care...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209788680598
更新日期:2009-07-01 00:00:00
abstract::Most of the HIV-infected long term survivors show strong CD8+ cell noncytotoxic antiviral response (CNAR) that plays as an important factor for maintaining the relative healthy state of infected individuals. HIV infected former blood donors (FBDs) in Anhui, China are the unique population that considered infected by t...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209788680561
更新日期:2009-07-01 00:00:00
abstract::After the infusion of HIV-1 virus into a host cell, RNA is reverse transcribed to dsDNA, which persists intracellular to the infected cell in a variety of forms. Numerous in-house assays have been developed for the quantification of the different cellular HIV-1 DNA forms; these implement conventional or real-time PCR ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209788348001
更新日期:2009-05-01 00:00:00
abstract::We recently described that the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid (compound A) inhibits the human immunodeficiency virus type 1 (HIV-1) enzyme reverse transcriptase (RT), and its replication in primary cells. Based on these findings, we per...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209788347958
更新日期:2009-05-01 00:00:00
abstract::The human immunodeficiency virus-1 (HIV-1) Vpr protein plays multiple roles in HIV-1 replication. In early infection, Vpr provides help in the nuclear localization of pre-integration complex. Subsequently, Vpr induces cell cycle arrest of infected cells at G2/M phase. Cell cycle arrest facilitates higher rate of viral...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209787581508
更新日期:2009-03-01 00:00:00
abstract:UNLABELLED:Some deficient genetic polymorphisms of the innate immune system have been correlated to a higher susceptibility to different infections, especially in immunocompromised patients. The possible association between an increased incidence of pneumococcal bacteremia in HIV-infected patients, and deficient polymo...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209787581382
更新日期:2009-03-01 00:00:00
abstract::Natural or experimental infection of the African sooty mangabey (SM) with the simian immunodeficiency virus (SIV) results in chronic high levels of virus replication but is associated with none of the debilitating immunopathology, including the marked CD4 T-cell depletion, persistent cell activation and acquired immun...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209787048465
更新日期:2009-01-01 00:00:00